Role of Aromatase Inhibitors (AIs) in Growth
Aromatase inhibitors (AIs) can be used during puberty to delay growth plate closure, extending the growth period and potentially increasing height. Aromatase is the enzyme responsible for converting testosterone into estrogen, and since estrogen triggers growth plate fusion, inhibiting aromatase helps maintain testosterone levels while reducing estrogenic effects on bone maturation.
Mechanism of Action
AIs block aromatase, reducing estrogen production.
Lower estrogen levels help keep growth plates open for a longer period, allowing more bone growth.
Clinical Evidence for Use in Growth Enhancement
Studies on AIs like anastrozole and letrozole in boys with delayed puberty or specific growth-related conditions suggest they can:
Delay the fusion of growth plates.
Increase projected adult height.
Maintain or enhance testosterone levels, which may support other aspects of puberty.
Dosing and Estrogen Management
Preferred AI: Aromasin (Exemestane) over Arimidex (Anastrozole) and Letrozole, primarily due to word of mouth from people I know, and the general heightmaxxing community.
Target Estrogen Range: 20-40 pg/mL for those aiming to prolong growth plate openness.
Recommended Dosage: 12.5 mg of Aromasin every other day should generally keep estrogen within this range for individuals not using exogenous testosterone.